ABSTRACT
Pathogenesis of the novel coronavirus infection COVID-19 is the subject of active research around the world. COVID-19 caused by the SARS-CoV-2 is a complex disease in which interaction of the virus with target cells, action of the immune system and the body’s systemic response to these events are closely intertwined. Many respiratory viral infections, including COVID-19, cause death of the infected cells, activation of innate immune response, and secretion of inflammatory cytokines. All these processes are associated with the development of oxidative stress, which makes an important contribution to pathogenesis of the viral infections. This review analyzes information on the oxidative stress associated with the infections caused by SARS-CoV-2 and other respiratory viruses. The review also focuses on involvement of the vascular endothelium in the COVID-19 pathogenesis. Патогенез новой коронавирусной инфекции COVID-19 является предметом активного изучения во всем мире. COVID-19, вызываемый SARS-CoV-2, представляет собой сложное заболевание, в котором тесно переплетено взаимодействие вируса с клетками-мишенями, действием иммунной системы и системной реакцией организма на эти события. Многие респираторные вирусные инфекции, включая COVID-19, вызывают смерть инфицированных клеток, активацию компонентов врожденного иммунитета и секрецию цитокинов воспаления. Все эти процессы ассоциированы с развитием окислительного стресса, который вносит важный вклад в патогенез вирусных инфекций. В данном обзоре проведен анализ информации об окислительном стрессе при инфекциях, вызываемых SARS-CoV-2 и другими респираторными вирусами. Основное внимание в обзоре уделено участию сосудистого эндотелия в патогенезе COVID-19.
ABSTRACT
Pathogenesis of the novel coronavirus infection COVID-19 is the subject of active research around the world. COVID-19 caused by the SARS-CoV-2 is a complex disease in which interaction of the virus with target cells, action of the immune system and the body's systemic response to these events are closely intertwined. Many respiratory viral infections, including COVID-19, cause death of the infected cells, activation of innate immune response, and secretion of inflammatory cytokines. All these processes are associated with the development of oxidative stress, which makes an important contribution to pathogenesis of the viral infections. This review analyzes information on the oxidative stress associated with the infections caused by SARS-CoV-2 and other respiratory viruses. The review also focuses on involvement of the vascular endothelium in the COVID-19 pathogenesis.